Tilling  Apothecary  Botany 
The Apothecary is used to brew potions with permanent game bonuses using resources generated from Tilling and Botany. Ascension does not reset or change any aspect in Apothecary, but Rebirthing will only reset Apothecary level. Potions already crafted remain, and can continue to be crafted if they've been crafted beyond level 1.
Cauldrons
Cauldrons are the upgradeable "skillers" of Apothecary, which are used to discover and brew potions. Potion () is increased by upgrading Value, and the rate of effect () is increased by upgrading Speed. The Apothecary EXP multiplier () is always constant per Cauldron, but increases based on each individual Cauldron position. Apothecary EXP is only generated when Cauldrons are active.
One free Cauldron is provided at the start, but up to 5 additional Cauldrons can be unlocked after reaching a designated H2O level and they're purchased with gold.
Unlock Req.  Cauldron 1  Cauldron 2  Cauldron 3  Cauldron 4  Cauldron 5  Cauldron 6 

Cost    20M  100B  500T  2.5QQ  12PC 
H2O Level    30  45  60  75  90 
Potions
Discovering Potions
In order to brew potions, they must first be discovered. This is done with the "New Potion" recipe, the first option on the draggable scroll bar that appears after clicking on a Cauldron.
The recipe takes one unlocked ingredient from Tilling and another from Botany. Each combination of ingredients discovers a random potion within a certain range of their combined rarity values. This means that it may take more than one brewing to discover a particular potion.
The combinations listed below are just one possible combination to discover the potion and may not be the best for you at all times.
For specific combinations of ingredients and their chances to unlock potions, visit SGResponse's "Potion Discovery" Sheet.
Regular Potions
Every discovered potion offers a weak bonus to start with, but can be upgraded by spending increasing amounts of resources from Tilling and Botany. Almost every potion bonus increases by the first level bonus of the potion as they're upgraded.
*Note: The brewing ingredients required to upgrade potions are not necessarily the same as the ones capable of discovering potions. Use this "Potion Discovery" Sheet for discovering potions.
Red Rarity
Level Req.  Potion  Per Level Bonus  

1  Mack Attack  1% Damage Every 10 Attack Levels  
2  Whey Cool EXP  12% EXP From All Gym Skillers  
3  Monster Cash  2% Cash from Enemies  
4  Crop Remedy  3% Tilling Crops for All Tillers  
5  Miracle Grow  4% Botany Growth Speed  
6  Ore Boostio  4% Ores Mined  
7  Based Damage  400 Base Damage  
8  Smith Redux  0.25% Reduced Total Smithing Cost (Caps at 90%) 
Orange Rarity
Level Req.  Potion  Per Level Bonus  

12  Strength Buster  1% Damage Every 10 Strength Levels  
13  Dojo Blood  15% EXP from All Dojo Skillers  
14  Cheap Pot  0.5% Cost of Potion Making (Caps at 90%)  
15  Flower Power  5% Flowers Gained for All Botany Pots  
16  Idle Pow Pow  5% Idle Damage  
17  Minor Miner  5% Mining EXP  
18  Big Farma  5% Botany EXP  
19  AP Cash Money  0.25% Monster Cash for Every Power of 10 AP Owned  
20  Scim Polish  Imbued Scimatars Give +3 More Base Damage Each  
21  Exotic Yield  10% Exotic Flowers 
Yellow Rarity
Level Req.  Potion  Per Level Bonus  

26  Smith Buff  1% Damage Every 10 Smithing Levels  
27  Rock Mixture  15% EXP from all Mountain Skillers  
28  Weed Speed  10% Botany Growth Speeds  
29  Idle Zoom  5% Idle Speed  
30  Serf Serum  10% Tilling EXP, 1% Tilling Speed  
31  Penguinzo  2% Critical Damage  
32  Bubblez  5% Cauldron Speed  
33  Gold Cash  0.5% Cash for Every Power of 10 Gold Ore Owned  
34  Ore Superbio  10% Ores Mined  
35  Ripperoo  Crystalline Rippers Give +15 More Base Damage Each  
36  Smith Reredux  0.5% Reduced Total Smithing Cost (Caps at 95%)  
37  Potion Dubble  2% Chance for Potions to Level Up Twice Instead of Once (Chance to Level Up Thrice at 100%+) 
Lime Rarity
Level Req.  Potion  Per Level Bonus  

42  HP Damagey  1% Damage Every 10 Endurance Levels  
43  Field Dew  15% EXP from All Field Skillers  
44  Pot Enabler  1 Max Upgradeable Flower Pot Speed Level (Bonus Increases by 1 Every 3 Levels)  
45  Croppin  12% Crops Gained  
46  OG Damage  1500 Base Damage  
47  Crusoda  4% Crusade EXP  
48  Growgrow  15% Botany Plants Given  
49  Big Winner  10% Cash from Enemies  
50  Riftion  8% Rift EXP  
51  Raw Power  12% Total Damage  
52  Hype Jar  30% Botany EXP Gained  
53  MineXP  15% Mining EXP  
54  Smith Stunter  Smithing Costs Go Up by 0.02% Less After Every Craft (Caps at 1.5%) 
Cyan Rarity
Level Req.  Potion  Per Level Bonus  

59  Water Goner  1% Damage Every 10 H2O Leves  
60  Sweat Cup  15% H2O EXP from Gym Skillers  
61  Smalloan  Start New Ascensions with (5+0.5*lvl)% of Cash Owned before Ascending (Caps at 99%)  
62  Flower Flow  40% Botany Growth Speed  
63  Krunkade  8% Critical Damage  
64  Idle Woosh  15% Idle Speed  
65  Exotic Mix  40% Exotic Flowers  
66  Oresome  25% Ores Mined  
67  Cashin Out  20% Cash from Enemies  
68  Distill Till  2% Tilling EXP, 0.2% Tilling Speed for Every Tilling Level  
69  Plant Vroom  50% Botany Plants Given  
70  Bigger Big  Big Ol' Swords Give +60 More Base Damage Each  
71  Smith Redoox  1% Reduced Total Smithing Cost (Caps at 98%) 
Purple Rarity
Level Req.  Potion  Per Level Bonus  

76  Spirit Hit  2% Damage Every 10 Spiriting Levels  
77  AP Tonic  10% AP Gained  
78  More Fast  1 Max Upgradeable Flower Pot Speed Level (Bonus Increases by 1 Every 2 Levels)  
79  Crop Pop  50% Crops Gained  
80  Idle Kachow  10% Idle Damage  
81  Peak Plant  +100 Botany EXP  
82  Irrelevance  4000 Base Damage  
83  Bargane  2% Cost of Potion Brewing (Caps at 95%)  
84  Thief N Gin  0.2% Cash for Every Level of Trinkets Crafted  
85  Totalitariat  40% Total Damage  
86  M Vitality  30% Max HP  
87  Converzin  2 Base Damage for Every 100 Base HP that You Have  
88  Smith Snail  Smithing Costs Go Up by 0.04% Less After Every Craft (Caps at 3%) 
Demon Rarity
Level Req.  Potion  Per Level Bonus  

94  Contract Pact  2% Damage Every 10 Contract Levels  
95  Trinko Gogo  Dubloon Trinkets Give +0.5% Cash Each  
96  Salve Labo  Enigmatic Booster from Smithing Boosts Botany Speed by 2% for Each Craft  
97  Criticola  20% Critical Damage  
98  Value Yumyum  10% Skiller EXP for Every 100 Value Upgrades Bought  
99  Till Recurve  0.5% Crops for Every Tilling Level  
100  Transfusion  1% Total Damage for Every +100% Total HP Bonus that You Have  
101  Bonkloot  2% Cash for Every Power of 10 Kills of Current Enemy  
102  Plant Vroom  3% Botany Growth Speed for Every Botany Level  
103  Limbo Luck  Increases Max Luck Upgrade Level by 1 in Spiriting Zone  
104  Canned Shield  50% Max Shields  
105  AP Powah  10% Damage for Every Power of 10 AP Owned  
106  Daedry  Smithing Costs Go Up By 0.04% Less After Every Craft (Caps at 4%) 
Godly Rarity
Cosmic Rarity
Level Req.  Potion  Per Level Bonus  Icecream  

126  Cygnus  Levels Up All Red, Orange and Yellow Potion Every Time This One Levels Up  
127  Lupinis  Oberon Obliterator Boost From Kills Increased To Power of 0.055% Fueled By Ensouled Heads  
128  Orniun  0.16% Chance for Exp Req to Not Go Up When You Level Up Your Strength Level  
129  Cepheus  +1.5 Max Cauldron Speed Upgrade Levels  
130  Persezia  0.16% Chance for Exp Req to Not Go Up When You Level Up Your Apothecary Level  
131  Auricia  2% Vessels Gain in Trekking  
132  Dippah  0.15% Chance for Exp Req to Not Go Up When You Level Up Your H2O Level  
133  Corvius  3% RP Gain for All Tanks  
134  Serpenzu  Levels Up All Green, Cyan and Purple Potion Every Time This One Levels Up  
135  Cantivici  0.13% Chain Level Chance  
136  Ophiucus  Levels Up All Demon and Godly Potion Every Time This One Levels Up 
Darkmode Potions
Among various things, Construction offers 4 upgrades, each for a new tier of potions. They are accessible via Apothecary screen (a toggle button in topright corner) once the first upgrade has been built. These potions require new crops and plants, which are also unlocked through Construction.
Brew Laddy
Level Req.  Cons. Lv.  Potion  Bonus  

154  1  Redemptsin  Failing To Get a New Flower Increases New Flower Chance by X%
(Only for Highest Plant)  
Tealy Drank  Leveling Up Fishing Has a X% Chance to Increase the Level of All 3 Power Upgrades  
Expendizzle  Tilling EXP Gain is Multiplied by X for Each New Crop Type Discovered  
2  Spunky Pop  Spelunking EXP Gain Increased by +X% Every Power of 10 Gold Skulls Owned  
Evoluzin  Chance to Hatch a New Pet is Increased by X% Every 20 Hatchery Levels  
Admite  Get a Permanent +X% Cash Bonus Every 10 Raid Tickets You Collect  
3  Treasurade  +X% Damage for Every Treasure You Have at Least 1 Million of
 
Diet Masty  Bonuses of the Mastery Perks Shown Below are Multiplied by X  
Purple Drank  Leveling Up Mining Has a X% Chance to Increase the Value LVL of All Six Miners  
4  Butof Course  EXP Gain for All 3 Pet Skills Increased by X%  
Crackin Yolk  10% Chance to Trigger an Eggshell Chain
 
Forewordi  times X Cash.

Brew Man
Level Req.  Cons. Lv.  Potion  Bonus  

1  Knowitall  Spelunk Learning Rate Increased by X%  
Keymeister  Get a Permanent +X% Damage Bonus Every 10 Asylum Keys You Collect  
Magno Booko  +X% Spelunker Speed per 10 Spelunking LVLs
 
2  Coca Prola  Increases the Maximum Bonus Upgrade LVL of Pro Rifts to X (Caps at 100)  
Brown Drank  Leveling Up Tilling Has a X% Chance to Increase the Value LVL of All Eight Tillers  
O Cal Masty  Bonuses of the Mastery Perks Shown Below Are Multiplied by X  
3  Olivertime  Dig Down Amount Increases X% Faster After Reaching the End of a Tunnel  
Gray Drank  Leveling Up Botany Has a X% Chance to Increase the Value and Speed LVL of All Pots  
Hybriseed  Machine Speed Increase per Construction Level is X% Higher  
4  Injurade  +X% Pet Damage Every 25 Percent of HP Your Team is Missing  
Yolks On Yolks  Gives the Crackin Yolk Potion +X% Chance to Trigger an Eggshell Chain (caps at +65%)  
Donut Bottle  Smithing Costs Go Up by a Minimum of X%

Brew Maestro
Level Req.  Cons. Lv.  Potion  Bonus  

1  Liste Ntoit  Crop Costs for Brewing Reduced by X% for Every Power of 10 Saharan Foals Owned  
Cascade  Leveling Up a Rift Has a X% Chance to Level Up the Rift to its Left (caps at 50%)  
Riche Biche  Spelunk Treasure is Worth X% More Every 10 Spelunking Level  
2  Macroppe  +X% Crusade Material Gain for Every Crusade Level Above 160
 
Cup Of Calm  +X% Extra Levels Gained When a Spelunker Absorbs  
Jug Of Storm  Learn Traits Can Now LVL Up by +X in a Single Absorb (caps at +15)  
3  Crimsi Drank  Leveling Up Apothecary Has a X% Chance to Increase the Value and Speed LVL of Cauldrons  
Cooooool  +X% Chance to Get Those Super Cool Tunnel Cards  
Nest Lea  +X% Chance to Double LVL Up When Upgrading a Hatchery Nest (No Double Charge!) (caps at +200%)  
4  Genetea  +X% Chance to Hatch a Pet with 2 or 3 Genes  
Trunkoke  Tank LVL Up Reqs are Reduced by X% for Every Power of 10 Green Vessels Owned  
Badonkadonk  +X% Ores Every 50 Balls Launched

Brew Bobby
Level Req.  Cons. Lv.  Potion  Bonus  

1  Hydrogenation  times X Damage Bonus Applied Y Times
 
Tressii  Increases the Max Perk Tree Upgrade LVL by +X
 
Certo Fizz  times X Flower Gain per Cert. Fish
Certification Req:
 
2  Certo Flav  times X Brew Speed per Cert. Flower
Certification Req:
 
Certo Ouzo  times X Crop Gain per Cert. Ore
Certification Req:
 
Certo Crum  times X Spelunk SPD per Cert. Crop
Certification Req:
 
3  Papa Fisto  Each Difficulty LVL Reached on the Final Crusade Boosts Doom Gauntlet by X  
Travitatee  This Potion Will Boost Afterlife Gains Later... Gives times X Ores for Now (caps at 2)  
Resoursake  Ore. Fish. Botany. Potion. Crusade. and Limbo Card Bonuses are Increased to the Power of X (caps at 2)  
4  Damagirdiente  Cash. Kills. Tunnels. and All Damage Card Bonuses are Increased to the Power of X (caps at 2)  
Baba Donakka  Badonkadonk Potion Now Boosts More Things (Fish. Crops. Flowers. Brew Speed. Dmg)
 
Nevasettle  Forewordi Potion Now Boosts More Things (Damage. Ores. Tank EXP. Crops)

Potion Coupons
The Gem Shop features five types of potion scrolls which can be used to automatically discover and level up a random potion. These coupons are simply clicked on the Apothecary screen in order to use them. Potions discovered using coupons can always be crafted, bypassing the level requirement.
Apothecary Bonuses
Cards
Unique Apothecary cards can be earned while brewing potions on the screen. Each potion color has its own card and any potion of the respective color has a chance of dropping one. The potions do not need to be leveling up in order for the cards to drop.
Crystals
Crystals can be inserted into crystal slots on each cauldron for bonuses. Both crystals and first crystal slots are unlocked through the Rebirth screen after clearing the Dungeon. Additional crystals, as well as the second and third crystal slots can be purchased through the Gem Shop.
The best placement of crystals can be found HERE.
Crystal Color  Bonus  

Yellow Crystal  +50% EXP  
Red Crystal  +30% Brew Speed  
Purple Crystal  +15% Cost Reduction  
Blue Crystal  +25% Double Brew Chance  
Green Crystal  +100% EXP, +150% Brew Speed, +50% Double Brew Chance  
Orange Crystal  +20% Bonus to all Crystals on Screen  
Pink Crystal  +200% Brew Speed to Slot and Adjacent Slots  
Black Crystal  +40% Cost Reduction to Slot and Adjacent Slots 
Other
 Perk tree perks:
 Training Perks:
 Rebirth perks:
 Mastery perks:
 Cards:
 Purgatory12, Confused Leg  Apothecary EXP (up to 30%),
 TheBog8, Magic Mushy  Double Brew Chance (up to 30%),
 TheBog12, Psyccidello  Potion Cost Redux (up to 18%),
 TheBog19, Disciple L  Apothecary EXP (up to 30%),
 LunarIsle23, Lunar Glitch  Potion Cost Redux (up to 30%),
 Oblivion1, Bean Baby  Apothecary EXP (up to 42%),
 Oblivion3, Glow Pop  Potion Brewing Speed (up to 60%),
 Oblivion17, Vile  Potion Cost Redux (up to 30%),
 Oblivion18, Putrid  Potion Prewing Speed (up to 96%),
 Crus.TheBog1, Loockey  Potion Prewing Speed (up to 48%),
 Crus.TheBog2, Merceneye  Double Brew Chance (up to 30%),
 Crus.LunarIsle5, Father Of All  Potion Brewing Speed (up to 120%).
 Potions:
 Tinkering gear:
 Pet Passives:
 ID19 Zebra, 30% brew speed per level,
 ID23 Polar King, +4 cauldron speed upgrades per level,
 ID28 Ice Cream, 50% brew speed per level,
 ID29 Crystal Bird, +5 cauldron speed upgrades per level,
 ID43 Platz, +15 cauldron speed upgrades per level,
 ID49 Sentinel R, 75% brew speed per level,
 ID50 Sentinel Y, +11 cauldron speed upgrades per level.
 Research Tanks:
 Asylum Shrines:
 Smithing crafts:
 Construction upgrades:
 Gem Shop purchases: